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(2) CGA promotes skin flap survival in rats by downregulating MDA and NO, upregulating GSH and SOD, and elevating VEGF expression and capillary density, leading to blood perfusion [306]
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However, one of the earliest recognized events is the formation of autoantibodies, particularly rheumatoid factor (RF), directed against the Fc fraction of immunoglobulin G (IgG) [5], as well as anti–cyclic citrullinated peptide antibodies (anti-CCP), generated from self-proteins that have undergone abnormal citrullination and are recognized as foreign by the immune system
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