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It is worth noting that metabolic networks possess remarkable plasticity, allowing them to reconnect and circumvent targeted treatments
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Indeed, melatonin is able to modulate orexinergic and anorexinergic neuropeptides, and its inhibitory action on orexin, mediated at least in part by MT1 receptors, could contribute not only to sleep regulation but also to energy balance [99, 119, 120]
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