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Oxidative stress leads to sperm dysfunction ( Genetic factors Genetic factors play an important role in the most serious spermatogenic disorders, such as severe oligozoospermia or azoospermia ( In infertile men, the incidence of chromosomal abnormalities has been reported to range from 5 to 15%, indicating that these abnormalities lead to non-obstructive azoospermia (NOA) ( AZF a (792 kb), AZF b (6.2 Mb), and AZF c (4.5 Mb) which contain several genes responsible for male fertility ( AZF c region containing eight gene families causes progressive deterioration of spermatogenesis and, consequently, azoospermia eventually leads to phenotypic changes in infertile men ( Spermatogenesis is thought to be regulated by as many as 2,000 genes, of which 600–900 genes seem to be expressed only in the male reproductive line