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They typically include a ligand-sensing receptor, often belonging to the nucleotide-binding domain leucine-rich repeat (NLR) family (such as NLRP1, NLRP3, NLRC4, or AIM2), an adaptor protein (usually the apoptosis-associated speck-like protein containing a CARD domain [ASC]), and a pro-caspase (typically pro-caspase 1) (77)
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