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Experiments have demonstrated that TMAO exhibits acute positive inotropic and lusitropic effects on human and mouse myocardium, significantly increasing intracellular calcium in ventricular cardiomyocytes (Oakley et al., 2020)
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To study the immunometabolic characteristics associated with response to CAR T cell therapy, we investigated the pre-infusion CAR T cell products and biological samples from a cohort of sixteen patients treated in our clinical trial, all of whom responded to CD19-CAR T cell therapy
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