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In intestinal epithelial cells, indole-3-propionic acid downregulates TNF-α and upregulates TJ-related proteins in a pregnane X receptor (PXR)-dependent manner ( Urolithin A (derived from polyphenols) also acts as a TJ modulator through AhR signaling ( Cldn4 , Ocln , and ZO-1 by inducing Cyp1A1 and Nrf2
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