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Heterogeneity testing revealed I 2 = 59.3%, indicating moderate heterogeneity, and a REM was used for analysis

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Autopsy examinations on tissue samples from PD patients have shown glial cell activation, α-synuclein aggregates, reduced SIRT1 activity, and increased expression of proinflammatory cytokines, such as IL-1β, which requires activation of the NLRP3 inflammasome for maturation and activation (Codolo et al., Figure 1)