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The closest FDA-approved IGF-1 product is mecasermin (Increlex) , native recombinant human IGF-1, approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or GH gene deletion with neutralizing antibodies

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The AUC to infinity (AUC ∞ ) was determined by extrapolation of the AUC 24 by using λ z