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These canonical functions positioned mGPDH as a redox-linked metabolic enzyme long before its recent recognition as a ferroptosis regulator via ubiquinol (CoQ 10 H 2 )-dependent antioxidant defense

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As ALDOA is the only aldolase isozyme expressed in erythrocytes and muscle, its deficiency is predicted to affect these tissues more severely than others as a consequence of impaired ATP generation (Wamelink, Valayannopoulos & Garavaglia, 2016)