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The results from this study may reveal an important basis underlying the gender-associated differences in the longevity and the susceptibility to certain age-related diseases, and also further suggest that the decreased synthesis, which is mainly due to the down regulation of GCL gene expression, may be responsible for the age-associated decline in GSH content
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Another study demonstrated that mouse podocytes, when exposed to IS for a prolonged duration, exhibited indications of a pro-inflammatory phenotype, a disrupted actin cytoskeleton, decreased expression of podocyte-specific genes, and diminished cell survival (65)
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