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Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues

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Clinical remission (measured by Simple Clinical Colitis Activity Index- SCCAI ≤2) was achieved by 53.8% of the curcumin group compared to none in the placebo group, and clinical response (≥3 point reduction in SCCAI) occurred in 65.3% of the curcumin group versus 12.5% in the placebo group

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