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Cagrilintide Research Protocols & Administration Dosing in Published Research Clinical trials have employed escalation protocols to optimize tolerability while achieving therapeutic doses: Initial dose: 0.25 mg weekly for weeks 1-4, escalating to 0.5 mg (weeks 5-8), 1 mg (weeks 9-12), 1.7 mg (weeks 13-16) Maintenance dose: 2.4 mg weekly starting at week 17 for combination therapy Monotherapy range: 0.3 mg to 4.5 mg weekly studied in phase 2 trials Combination therapy: 2.4 mg cagrilintide with 2.4 mg GLP1 in phase 3 studies Important: These are investigational doses used in human clinical trials