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PDB-101: Molecule of the Month: Glutathione Transferases

Androgens, whether in excess (Hyperandrogenism) or in deficiency (Hypoandrogenism), cause oxidative stress by affecting immunological responses, fostering chronic inflammation, causing mitochondrial dysfunction, and causing oxidative damage in reproductive organs, thereby affecting fertility and reproductive health ( Table 1 )

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This damage increases BBB permeability and disrupts its selective barrier function, facilitating the entry of inflammatory mediators and harmful substances into the brain parenchyma, which initiates neuroinflammation [94]