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In db/db mice, administration of M-920, a caspase inhibitor, reduced renal CASP1, IL-1β, IL-18, and NLRP3 inflammasome activation, leading to amelioration of albuminuria and renal ECM accumulation (198)
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Moreover, fatty acid and protein metabolisms were not studied because of their association to the glucose metabolism, therefore, impaired glucose metabolism would certainly affect these pathways
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