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655 Omega-3 supplementation: In a single-arm, open-label trial of seal oil ω-3 PUFA supplementation (composed of eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) for 1 year in patients with T1DM and diabetic sensorimotor polyneuropathy, a 29% improvement in the primary endpoint of corneal nerve fiber length was observed
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In continuation of our efforts to develop ERR pan agonists (Shahien et al., 2020), we recently reported the development of an ERR agonist, SLU-PP-332, that targets all three ERR isoforms, allowing for evaluation of this unique class of agent in vivo
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