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Because tyrosine differs from phenylalanine by a single hydroxyl group, AOD9604 and the unmodified 176-191 sequence are both 16-residue peptides that differ by exactly one oxygen atom — 1,815.1 g/mol versus 1,799.1 g/mol

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α-synuclein contains 140 residues and consists of three domains: the N-terminal lipid-binding α-helix residues 1–60, amyloid-binding central domain (NAC) residues 61–95, and C-terminal acidic tail residues 96–140 (Wang C