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Regardless, the majority of the studies presented in this review characterize the relationship of the GH/IGF-1 axis and the gut microbiome in animal models (in which many of these factors can be tightly controlled) and have not delved into these additional factors

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In addition to LPS, microbial metabolites such as deoxycholic acid (DCA), ethylphenol, and microbially derived acetaldehyde also contribute to hepatic dysfunction through direct toxic effects and by activating hepatic nuclear receptors such as FXR and PXR [64]

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