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In addition to the liver, circulating Cu can also be taken up by other tissues and organs, including the heart, skeletal muscle, and brain (Linder et al., 1998)
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Oltipraz (4-methyl-5-[2-pyrazinyl]-1,2-dithiole-3-thione) is an Nrf2 inducer that suppresses the benzo[a]pyrene-induced gastric cancer formation, which is not observed in Nrf2 -null mice (Ramos-Gomez et al., 2001)
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