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However, in AML harboring TP53 mutations, DTP cells are arrested in G2/M phases of cell cycle, elimusertib inhibits the expression of the G2/M-phase cell-cycle checkpoints regulators (including cdc25c, p-CDK1, and Cyclin b) to reactivate the cell cycle thereby resensitize to treatments (Kim et al., 2024)
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This interaction results in the upregulation of Gln transporters SLC38A2 and SLC7A5, facilitating Gln uptake by lung cancer cells and promoting tumor proliferation (58)
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