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ROC analysis affirmed their high discriminatory value (AUC ≥ 0.7), with a combined model demonstrating good performance

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Loss of CCP1 or CCP5 results in pathological hyperglutamylation that precedes and drives progressive structural disorganization of the outer segment, characterized by destabilization of the distal axoneme, loss of the bulge region required for disc formation, and severe impairment of IFT