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The rationale and perspectives for using colchicine in the treatment of MPNs were described earlier in ( 2.5.1 Mechanistic rationale in MPNs Targeting Inflammation: Colchicine potently dampens inflammation by disrupting the assembly and activation of the NLRP3 inflammasome (117–119), thereby reducing release of the pro-inflammatory cytokines IL-1 β and IL-18 (120–122)