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In parallel, preclinical models demonstrate that NLRP3 activation and downstream pyroptosis-related signaling correlate to schizophrenia-like behavioral abnormalities, including social and cognitive deficits, while pharmacologic inhibition of NLRP3 attenuates these behaviors [73, 77, 196, 198, 199]
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doi: 10.1016/j.biomaterials.2013.01.096
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