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Of ROS molecules, non-radical hydrogen peroxide (H 2 O 2 ) and typical free radicals of hydroxyl radical (•OH) and superoxide anion radical (O 2 •− ) have been well studied and are considered among the key players in cellular damage [19]

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Monotherapy protocols are commonly initiated at 0.6 mg per week and escalated to a maximum studied dose of 4.5 mg as tolerated