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Results Fibroblasts from a TARDBP -ALS family show an increased proliferation rate and a higher ATP production with respect to control cells We collected a representative cohort of fibroblasts derived from an Italian fALS-family [16] with carriers of the c.1127 G→A mutation in the TARDBP gene (coding for TDP-43 G376D ) to study the role of TARDBP mutations in ALS and the contribution of familiar genetic traits to the disease