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The implantation procedure inevitably disrupts host barriers and alters local immune homeostasis, resulting in a peri-implant microenvironment characterized by excessive inflammation, oxidative stress, and impaired antimicrobial activity of innate immune cells such as neutrophils and macrophages 272
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doi: 10.1016/s1471-4914(03)00109-6 168 NielsenS.NagelhusE
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