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The following considerations further strengthen the criticism toward the use of PAC as a safer alternative to NSAID: PAC has been preferred to NSAIDs and steroids for the symptomatic and domiciliary management of the early stages of COVID-19, a choice grounded of the precautionary principle (but still theoretical in this specific case) principle “ primum non nocere ” (Micallef et al., 2020a)
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One factor that could explain the discordance among the prevalence data of DAO deficit in patients with disorders associated with histamine intolerance is that the parameter considered in all of them was serum DAO activity, which, a priori, would not reflect an enzymatic deficiency derived from certain intestinal pathologies
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