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335,336 The expression of iNOS is primarily activated by the NF-κB pathway, which is activated and translocated to the nucleus upon inflammatory stimulation (such as bacterial endotoxins or pro-inflammatory cytokines), thus increasing the transcription and expression of iNOS
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Deficit in GSH may precede the neuropathology of these diseases, and neuronal GSH depletion may be one of the primary causes of initial brain damage in AD
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