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41589_2021_915_MOESM12_ESM.mpeg Supplementary Video 10 Representative movie for 100 ns MD simulation of WT GPX4 with the camera zoomed in for a close-up of the active site
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Binding to and phosphorylation of Sab by p-JNK leads to inactivation of p-Src on the inner mitochondrial membrane, which then inhibits electron transport and increases reactive oxygen species release [54,60], thus amplifying oxidant stress and peroxynitrite formation [42]
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