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Likewise, caffeic acid itself directly inhibited ERK1/2 (MAPK) activity in melanoma and epidermoid carcinoma cells, disrupting a key pathway that promotes tumor growth and migration (150)
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Generally, 2OGO catalyze specific hydroxylation of substrates, which, in turn, leads to demethylations via other catalytic cycles or downstream pathway involving thymine-DNA-glycosylase, which catalyzed base excision with DNA base excision repair [101,120]
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