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The PIONEER 6 Phase III study enrolled diabetics with cardiovascular disease in order to exam oral semaglutide PK and PD in this cohort to see if the daily 14-mg formulation increases cardiovascular risk [75]
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415 Even in healthy adults, autocrine VEGF is essential for blood vessel homeostasis, as endothelial-specific deletion of Vegf results in progressive endothelial degeneration
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