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For instance, high doses of antioxidants like beta-carotene or vitamin E may not always be beneficial and could even exacerbate oxidative damage, particularly before exposure to harmful agents like radiation or cigarette smoke (51)

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The upregulation of arginase activity and oxidative stress-induced eNOS uncoupling interact, forming a vicious cycle that synergistically reduces NO} bioavailability and ultimately impairs }the endothelium-dependent vasodilation regulatory mechanism (55)