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the Interference Region contains the effector module (crRNA) and target binding genes and comprise cas7, cas5, SS and caslO genes followed by a signal transduction/ancillary gene region containing CRISPR- Associated Rossman fold (CARF) regions and a HEPN domain (higher eukaryotes and prokaryotes nucleotide-binding domain
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A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
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