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Although conventional MRI techniques are sensitive to changes in total iron concentration, they lack the chemical specificity needed to distinguish between different iron pools, such as toxic redox-active iron and protective iron safely stored within proteins like ferritin (115)

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Likewise, in datasets GSE135251 ( n = 206) and GSE126848 ( n = 57) unsupervised machine learning discerned a “red” cluster with increased gene expression for PUFA incorporation, theoretically sensitizing toward ferroptosis, combined with decreased expression of ferroptosis defenses