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Subsequent efforts to identify the enzyme responsible for cGAMP production led to the characterization of cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor that directly binds double-stranded DNA and catalyzes cGAMP synthesis upon activation (Sun et al., 2013)
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This reduces oxidative DNA damage within melanocytes, diminishing the triggers that upregulate melanin production in the first place
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