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Different parameters could modulate tolerance such as the opioid agonist used (Enquist et al., 2012), duration of treatment (Soignier et al., 2004), doses (Huidobro et al., 1976) and even the pharmacological effect observed (Mohammed et al., 2013)
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In all the five studies, an oral (Delpre’s study via sublingual route) dose of 1000 μg vitamin B 12 was used with the exception of Kuzminski’s study, whereby a higher dose of 2000 μg was used
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