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The Saline versus Albumin Fluid Evaluation (SAFE) study, which randomly assigned 6997 critically ill patients to 4% albumin or isotonic sodium chloride solution for fluid resuscitation during the 28 days after ICU admission, found no differences in 28-day all-cause mortality, ICU or hospital length of stay, or duration of mechanical ventilation or renal replacement therapy

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It has been reported that herbal compounds such as α-mangostin and gambogic acid inhibit the p53- Mouse double minute 2 homolog (MDM2) interaction by binding to MDM2 (Parks et al., 2005)