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35 The evolutionarily conserved, ~90-residue-long PDZ sequence allows the scaffolding proteins to perform two major functions: 1) anchoring the intracellular C-terminus of transmembrane proteins (TJs, ion channels, receptors, etc.) and 2) establishing scaffolding networks via interactions with other PDZ proteins through PDZ–PDZ dimerization
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These outcomes reflect observed biomarker and pathway changes under controlled conditions and are not established therapeutic claims
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