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Similar to the previous cases, quantification of the synergy by MuSyC for AXT050 and rilotumumab at steady state revealed an inconsequential synergistic efficacy ( β obs = 0.013 and 0.007 for pAkt and pERK, respectively) and antagonistic potency (log( α 2 ) = −0.31 and −0.10 for pAkt and pERK, respectively)
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by dehydroascorbate reductase (see Fig
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