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Bowers and colleagues published a landmark 1990 study in the Journal of Clinical Endocrinology and Metabolism in 18 normal adult men that used IV bolus GHRP (0.1, 0.3, 1.0 mcg/kg) alone and combined with GHRH (1.0 mcg/kg), where peak GH rose from 1.2 ± 0.3 mcg/L on placebo to 7.6 ± 2.5, 16.5 ± 4.1, and 68.7 ± 15.5 mcg/L at ascending GHRP doses (approximately 6- to 57-fold), with submaximal GHRP plus GHRH producing synergistic responses exceeding the sum of either alone

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tracer — labeled glucose for assessing its fluxes