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Independent work from the Evans laboratory confirmed the gain-of-function counterpart: a 2023 study by Xia, Scholtes, Dufour, and colleagues in Molecular Metabolism showed that genetic activation of ERRα in mouse skeletal muscle drove myofiber aerobic transformation — increased oxidative myofibers, angiogenesis, mitochondrial biogenesis, and fat oxidation — and enhanced running endurance and fatigue-resistance without exercise training
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This compound is widely studied in tissue repair, angiogenesis, and inflammation research models and is used in controlled laboratory environments to investigate cellular repair mechanisms, nitric oxide pathways, and healing response interactions across multiple biological systems
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